A novel human leukocyte antigen-A*33:44 allele revealed by sequence analysis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 85-87, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-254502
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the sequence of a novel human leukocyte antigen (HLA)-A*3344 allele.</p><p><b>METHODS</b>A novel HLA-A allele was found by double-stranded sequencing combined with single-stranded sequencing. The frequency of the novel allele was determined by population survey.</p><p><b>RESULTS</b>Genomic sequence of this novel HLA-A*3344 allele (accession No. HQ873871) has differed from HLA-B*330301 by one nucleotide in exon 4, which resulted in nt 866 G→ A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265. This alternation is a new single nucleotide polymorphism compared with other HLA-A alleles. The frequency of this new allele is less than 0.0003 in Chinese Han population.</p><p><b>CONCLUSION</b>A mutation has been found in exon 4 of the novel HLA-A*3344 allele, which may provide more information for HLA gene study.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antígenos HLA-A
/
Análisis de Secuencia de ADN
/
Sustitución de Aminoácidos
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Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Alelos
/
Genética
/
Métodos
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2014
Tipo del documento:
Artículo
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