Application of ROC curve for evaluation of the effect of prenatal screening during second trimester of pregnancy / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 616-618, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-254550
ABSTRACT
<p><b>OBJECTIVE</b>To develop a method for evaluating the feasibility of prenatal screening using local median value and determining the cut-off value.</p><p><b>METHODS</b>With receiver operating characteristic curve (ROC) analysis, results of second trimester prenatal screening calculated by a local median value in a new model and the built-in median value in 2T software were compared. The cut-off value was set by serial analysis of true and false positive rates and other relevant data.</p><p><b>RESULTS</b>The ROC curve has accurately estimated the difference in the screening efficacy between a local median value and that embedded in the 2T model, and established a reasonable cut-off value for the laboratory based on false positive rate and detection rate.</p><p><b>CONCLUSION</b>The method of ROC curve can be used to evaluate the performance of local median value in prenatal screening and to test the rationality of cut-off value established in the laboratory. As the result, a better cut-off value may be derived.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Segundo Trimestre del Embarazo
/
Diagnóstico Prenatal
/
Estándares de Referencia
/
Programas Informáticos
/
China
/
Epidemiología
/
Curva ROC
/
Síndrome de Down
/
Diagnóstico
/
Genética
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
/
Masculino
/
Embarazo
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2013
Tipo del documento:
Artículo
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