Effect of vasonatrin peptide on the Ca2+ activated K+ channels of vascular smooth muscle cells isolated from rat mesentery arteries / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 94-97, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-254596
ABSTRACT
<p><b>AIM</b>To investigate effect and mechanism of vasonatrin peptide (VNP) on Ca2+ activated K+ channels (K(Ca)) of vascular smooth muscle cells (VSMCs) isolated from rat mesentery arteries.</p><p><b>METHODS</b>Changes of K(Ca) induced by VNP were measured by the means of whole cell recording mode of patch clamp, furthermore effects of HS-142-1(0.3 g/L), 8-Br-cGMP and methylene blue (MB) were observed.</p><p><b>RESULTS</b>K(Ca) was significantly enhanced by VNP (10(-6) mol/L), which was mimicked by 8-Br-cGMP(10(-3) mol/L) and blocked completely by HS-142-1 or MB (2 x 10(-5) mol/L).</p><p><b>CONCLUSION</b>VNP increases K(Ca) of VSMCs isolated from rat mesenteric arteries, by binding with natriuretic peptide guanylate cyclase-coupled receptors and increasing the intracellular level of cGMP in VSMCs.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Factor Natriurético Atrial
/
Ratas Sprague-Dawley
/
Biología Celular
/
Canales de Potasio Calcio-Activados
/
Arterias Mesentéricas
/
Metabolismo
/
Músculo Liso Vascular
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2006
Tipo del documento:
Artículo
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