Chromosomal aberration in human keloid analyzed by comparative genomic hybridization / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify the genetic alteration in human keloid.</p><p><b>METHODS</b>Comparative genomic hybridization was applied in 6 cases of keloid to investigate the genomic imbalance (the gain or loss of genetic material).</p><p><b>RESULTS</b>The study showed that the loss of chromosome DNA copies included chromosome, 1,7,9,13,16,17,18,19,20,22. Among them, the frequently detected chromosome loss was chromosome 1 p(66.7%), 16 (83.3%), 20 (83.3%) and 22 (83.3%). The minimum overlapping regions were 1 pter-32.2,16p13.2p11.l,20q11.1-q13.2 and 16p13.2-p11.1. Frequent gain of DNA copy numbers was not found in the special regions.</p><p><b>CONCLUSIONS</b>The mapping of DNA copy variation frequency in keloid showed that there may be inhibitory genes in chromosomes 1p,16,20,22. The loss of these genes may be involved in the development and progress of keloid.</p>