Antiepileptic effect of low-frequency electrical stimulation is waveform-dependent in hippocampal kindled mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 315-322, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-255193
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the waveform of electrical stimulus affects the antiepileptic effect of focal low-frequency stimulation (LFS).</p><p><b>METHODS</b>The antiepileptic effects of the LFS in sine, monophase square and biphase square waves were investigated in hippocampal kindled mice, respectively.</p><p><b>RESULTS</b>Compared to the control group, sine wave focal LFS (30 s) inhibited seizure stages (2.85 ± 0.27 vs 4.75 ± 0.12, P<0.05), lowered incidence of generalized seizures (53.6% vs 96.5%, P<0.01) and reduced afterdischarge durations [(16.2 2 ± 1.69)s vs (30.29 ± 1.12)s, P<0.01] in hippocampal kindled mice, while monophase or biphase square wave LFS (30 s) showed no antiepileptic effect. Monophase square LFS (15 min) inhibited seizure stages (3.58 ± 0.16, P<0.05) and incidence of generalized seizures (66.7%,P<0.01), but had weaker inhibitory effect on hippocampal afterdischarge durations than sine wave LFS. In addition, pre-treatment and 3 s but not 10 s post-treatment with sine wave LFS resulted in suppression of evoked seizures (P<0.05 or P<0.01).</p><p><b>CONCLUSION</b>The antiepileptic effect of LFS is dependent on its waveform. Sine wave may be optimal for closed-loop LFS treatment of epilepsy.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Convulsiones
/
Estimulación Eléctrica
/
Epilepsia
/
Hipocampo
/
Excitación Neurológica
/
Anticonvulsivantes
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2015
Tipo del documento:
Artículo
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