Research advances on ubiquitin C-terminal hydrolase in oncogenesis and progression / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 217-222, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-255208
ABSTRACT
By regulating the ubiquitination and deubiquitination of key proteins, ubiquitin-proteasome system mediates a variety of cellular activities. Ubiquitin C-terminal hydrolase (UCH) is a deubiquitinating enzyme which can remove ubiquitin chains at the end of ubiquited proteins. The abnormal expression of UCH has been found in a variety of tumor tissues, indicating that it participates in the process of tumor development. Here we review the characteristics of UCH members and current understanding about the role of UCH in tumor development, and the potential target for cancer treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Progresión de la Enfermedad
/
Ubiquitina
/
Ubiquitina Tiolesterasa
/
Carcinogénesis
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2015
Tipo del documento:
Artículo
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