Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 211-216, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-255209
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Transducción de Señal
/
Cadherinas
/
Factor de Crecimiento Transformador beta
/
MicroARNs
/
Transición Epitelial-Mesenquimal
/
Vía de Señalización Wnt
/
Metástasis de la Neoplasia
/
Recurrencia Local de Neoplasia
/
Neoplasias
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2015
Tipo del documento:
Artículo
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