Expression of vascular endothelial growth factor in human placental trophoblasts and angiogenesis in the chorionic villi / 南方医科大学学报
Journal of Southern Medical University
; (12): 505-508, 2006.
Article
en Zh
| WPRIM
| ID: wpr-255270
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of vascular endothelial growth factor (VEGF) in human placental trophoblasts and the role of VEGF in regulating placental villous angiogenesis.</p><p><b>METHODS</b>Placental samples were obtained from 10 pregnant women receiving induced abortion in the first trimester, 10 receiving induced labor in the second trimester and 10 having cesarean section at term delivery, with gestational duration of 6-9, 18-22 and 37-38 weeks, respectively. All the samples were fixed in formalin solution and prepared for the morphological study. The expression of VEGF and vascular distribution in the placental villi were examined and evaluated by immunohistochemistry and stereomorphometry, respectively.</p><p><b>RESULTS</b>In the course of pregnancy, there was a significant decrease in the level of VEGF expression in chorionic villi (28.19+/-3.01, 18.65+/-2.43, 4.95+/-0.86, respectively, P<0.01). The radial parameters of the blood vessels showed no significant changes (26.67+/-7.74, 25.08+/-4.67, 23.36+/-5.30, respectively, P>0.05), but the length density of the blood vessels increased significantly (1.46+/-0.64, 5.58+/-1.31, 19.56+/-1.40, respectively, P<0.01).</p><p><b>CONCLUSION</b>During gestation, VEGF expression in chorionic villi gradually weakens but the length density of the blood vessels increases, indicating that VEGF is not the only regulatory factor of angiogenesis in the chorionic villi.</p>
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1
Índice:
WPRIM
Asunto principal:
Fisiología
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Placenta
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Trofoblastos
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Vellosidades Coriónicas
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Edad Gestacional
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Neovascularización Fisiológica
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Factor A de Crecimiento Endotelial Vascular
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Metabolismo
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2006
Tipo del documento:
Article