Clinicopathological and immunohistochemical analysis of gastrointestinal, urinary and perineal stromal tumors / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 111-114, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-255354
ABSTRACT
<p><b>OBJECTIVE</b>To study the histogenesis and pathological characteristics of gastrointestinal stromal tumors (GIST) and GIST type stromal tumor (ST) beyond the gastrointestinal tract.</p><p><b>METHODS</b>A retrospective study was carried out on leiomyoma, leiomyosarcoma and neurilemoma (46 cases in gastrointestinal tract and l3 cases in urinary tract and perineal area). 4 antibodies (CD117, CD34, SMA, S-100) were used for immunohistochemical staining.</p><p><b>RESULTS</b>Among 45 cases of GIST, the positive rate of CD117 and CD34 was 93.3% and 88.9% respectively. Among 12 cases of GIST type ST beyond the gastrointestinal tract, the positive rate of CD117 and CD34 was 83.3% and 75.0% respectively. In 2 cases (1 in gastrointestinal tract) of leiomyomas, both CD117 and CD 34 were negative in tumor cells, while SMA was extensively positive.</p><p><b>CONCLUSIONS</b>CD117 and CD34 positivity are the most valuable factors in diagnosing ST. Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.</p>
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias Pélvicas
/
Perineo
/
Inmunohistoquímica
/
Proteínas S100
/
Biomarcadores de Tumor
/
Química
/
Estudios Retrospectivos
/
Actinas
/
Neoplasias Urológicas
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2003
Tipo del documento:
Artículo
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