Tissue transglutaminase protein expression in human brain tumors / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 31-34, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-255361
ABSTRACT
<p><b>OBJECTIVE</b>To investigate expression of tissue transglutaminase (tTG) protein and its role in carcinogenesis of brain tumors.</p><p><b>METHODS</b>tTG protein was detected by immunohistochemical method in 62 astrocytomas, 18 oligodendrogliomas, 30 benign meningiomas, 30 pituitary adenomas and 10 normal brain tissues.</p><p><b>RESULTS</b>(1) In brain tumors, tTG protein expression was heterogeneous locating in tumor and endothelial cells. (2) Immunoreactivity of tTG protein was significantly different between different grades of astrocytomas. (3) Expression intensity of tTG protein in glioma was higher than that in benign brain tumors. (4) Strong expression of tTG protein in tumor cell was obtained around the necrosis foci and apoptotic cells in astrocytomas.</p><p><b>CONCLUSIONS</b>tTG protein expression contributed to tumor malignant progression in malignant brain tumors.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oligodendroglioma
/
Patología
/
Astrocitoma
/
Neoplasias Encefálicas
/
Inmunohistoquímica
/
Transglutaminasas
/
Apoptosis
/
Proteínas de Unión al GTP
/
Células Endoteliales
Límite:
Adolescente
/
Adulto
/
Anciano
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2003
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS