Clinicopathologic significance of chromosomal DNA sequence copy number aberrations in patients with colorectal carcinoma / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To analyze the correlation of DNA sequence copy number aberrations (DSCNAs)with clinicopathologic parameters in patients with colorectal cancer(CRC).</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) method was used in analysis of 73 cases with CRC. Statistical analysis was performed using Stat View statistical software package(5.0).</p><p><b>RESULTS</b>Loss of 8pl2-pter and gain of 8q23-qter were linked to nodal metastasis, while loss of 18q12-qter and gain of 8q23-qter were associated with distant organ metastasis at diagnosis and (or) recurrence after surgery. Moreover, losses of 8pl2-pter and 18q12-qter and gain of 8q23-qter were associated significantly with unfavorable prognosis. Multivariate analysis revealed that loss of 18q12-qter was an independent prognostic marker.</p><p><b>CONCLUSION</b>Our findings indicate that genetic aberrations detected by CGH may predict outcome in patients with CRC, and may provide useful information for clinical treatment. Comparative genomic hybridization;</p>