Dose dense chemotherapy in the postoperative adjuvant treatment for breast cancer / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the safety and feasibility of dose dense chemotherapy in the postoperative adjuvant treatment for breast cancer.</p><p><b>METHODS</b>The data of 114 breast cancer patients treated with adjuvant dose dense chemotherapy was retrospectively analyzed.</p><p><b>RESULTS</b>114 breast cancer patients received postoperative adjuvant dose dense chemotherapy from Jan. 2004 to March 2005. The patients were treated with different regimens according to their recurrence risk 43 with paclitaxel + epirubicin (PE), 8 with taxotere + epirubicin (TE), 36 with cyclophosphamide + epirubicin + 5-Fu ( CEF) and 27 with epirubicin +5-Fu (EC). Totally, 111 patients except 3 completed the dose dense chemotherapy smoothly. Major toxicities severer than grade III included neutropenia in 6.3% of the patients, nausea and vomit in 11.7%, peripheral neuropathy in 3.6%.</p><p><b>CONCLUSION</b>Postoperative adjuvant dose dense chemotherapy for breast cancer patient is feasible and safe, but the long-term outcome still needs further observation.</p>