Pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 548-550, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-255843
ABSTRACT
<p><b>OBJECTIVES</b>To study clinical characteristics and outcome of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>Variables including sex, age, stem cell source, granulocyte engraftment time, blood transfusion and isoagglutinin type against donor RBC were analyzed to identify risk factors for the development of PRCA.</p><p><b>RESULTS</b>Twelve of 100 patients received major ABO-incompatible allo-HSCT developed PRCA, with out any effect on incidence of aGVHD and CMV infection. ABO blood groups of recipient/donor pairs of these twelve PRCA patients were O/A in nine, B/A in one and O/B in two. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than those with anti-B (10/49 vs 2/49). Median duration to the recovery of erythropoiesis tended to be longer in patients with PRCA (PRCA vs non-PRCA, 203.5 vs. 76 days, P < 0.05 ). Median durations to the disappearance of incompatible isoagglutinins tended to be longer in patients with PRCA (PRCA vs. non-PRCA, 150.5 vs. 60 days,P <0.05) and in those with anti-A isoagglutinins (anti-A vs anti-B, 90 vs 55 days, P < 0.05).</p><p><b>CONCLUSION</b>ABO blood group of O/A in recipient/donor pair was the only high risk factor for PRCA after major ABO-incompatible allo-HSCT.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Complicaciones Posoperatorias
/
Pronóstico
/
Terapéutica
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Incompatibilidad de Grupos Sanguíneos
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Sistema del Grupo Sanguíneo ABO
/
Estudios Retrospectivos
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Factores de Riesgo
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Aplasia Pura de Células Rojas
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Trasplante de Células Madre Hematopoyéticas
/
Alergia e Inmunología
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2005
Tipo del documento:
Artículo
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