Progress of study on p62 and protein degradation pathways / 生理学报
Acta Physiologica Sinica
;
(6): 48-58, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-255973
ABSTRACT
The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a component within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions. Importantly, p62 plays a critical role in cell's selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives on p62 research.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Autofagia
/
Estrés Oxidativo
/
Ubiquitina
/
Complejo de la Endopetidasa Proteasomal
/
Proteínas Adaptadoras Transductoras de Señales
/
Dominios y Motivos de Interacción de Proteínas
/
Proteolisis
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2015
Tipo del documento:
Artículo
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