Primary research of pharmacological effects of PEC on mice / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.</p><p><b>METHOD</b>Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.</p><p><b>RESULT</b>When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.</p><p><b>CONCLUSION</b>PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.</p>