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Influence of sargassum fusiforme polysaccharide on apoptosis of tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 245-247, 2004.
Artículo en Chino | WPRIM | ID: wpr-256379
ABSTRACT
<p><b>OBJECTIVE</b>To study mechanism of antitumor activity of Sargassum Fusiforme Polysaccharide (SFPS).</p><p><b>METHOD</b>The effect on cell cycle and apoptosis was studied with flow cytometry (FCM). Intracellular calcium concentration [Ca2+]i was marked with Fluo-3/AM and measured with laser scanner confocal microscope (LSCM).</p><p><b>RESULT</b>SFPS inhibited G0/G1 stage SGC-7901 from entering to S stage and increased APO%. The [Ca2+]i showed a transient rise and return to the original level. The concentration could be raised again by administering CaCl2.</p><p><b>CONCLUSION</b>The antitumor effect of SFPS seems to be accomplished through the apoptosis associated with the increase in intracellular calcium concentration. Intracellular stores release the calcium during its action.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Polisacáridos / Neoplasias Gástricas / Cloruro de Calcio / Células Tumorales Cultivadas / Ciclo Celular / Química / Calcio / Apoptosis Límite: Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2004 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Farmacología / Polisacáridos / Neoplasias Gástricas / Cloruro de Calcio / Células Tumorales Cultivadas / Ciclo Celular / Química / Calcio / Apoptosis Límite: Humanos Idioma: Chino Revista: China Journal of Chinese Materia Medica Año: 2004 Tipo del documento: Artículo