Influence of sargassum fusiforme polysaccharide on apoptosis of tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 245-247, 2004.
Artículo
en Chino
| WPRIM
| ID: wpr-256379
ABSTRACT
<p><b>OBJECTIVE</b>To study mechanism of antitumor activity of Sargassum Fusiforme Polysaccharide (SFPS).</p><p><b>METHOD</b>The effect on cell cycle and apoptosis was studied with flow cytometry (FCM). Intracellular calcium concentration [Ca2+]i was marked with Fluo-3/AM and measured with laser scanner confocal microscope (LSCM).</p><p><b>RESULT</b>SFPS inhibited G0/G1 stage SGC-7901 from entering to S stage and increased APO%. The [Ca2+]i showed a transient rise and return to the original level. The concentration could be raised again by administering CaCl2.</p><p><b>CONCLUSION</b>The antitumor effect of SFPS seems to be accomplished through the apoptosis associated with the increase in intracellular calcium concentration. Intracellular stores release the calcium during its action.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Polisacáridos
/
Neoplasias Gástricas
/
Cloruro de Calcio
/
Células Tumorales Cultivadas
/
Ciclo Celular
/
Química
/
Calcio
/
Apoptosis
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2004
Tipo del documento:
Artículo
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