Role of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in rheumatic diseases / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3898-3904, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-256621
ABSTRACT
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of structurally related cytokines and is known to induce proliferation, migration, differentiation, apoptotic cell death, inflammation, and angiogenesis. These physiological processes are induced by the binding of TWEAK to fibroblast growth factor-inducible 14 (Fn14), a highly inducible cell-surface receptor that is linked to several intracellular signaling pathways, including the nuclear factor-κB (NF-κB) pathway. This review discusses the role of the TWEAK-Fn14 axis in several rheumatic diseases and the potential therapeutic benefits of modulation of the TWEAK-Fn14 pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Artritis Reumatoide
/
Esclerodermia Sistémica
/
Enfermedades Reumáticas
/
Receptores del Factor de Necrosis Tumoral
/
Factores de Necrosis Tumoral
/
Citocina TWEAK
/
Receptor de TWEAK
/
Lupus Eritematoso Sistémico
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2012
Tipo del documento:
Artículo
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