A meta-analysis of feasibility and safety in complete mesocolic excision for colon cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 74-80, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-256814
ABSTRACT
<p><b>OBJECTIVE</b>To systemically assess the feasibility and safety of complete mesocolic excision (CME) for colon cancer.</p><p><b>METHODS</b>A computer-based online research of prospective, randomized or nonrandomized, controlled studies addressing CME versus traditional surgery published in the last five years was performed in electronic databases (Wanfang Database, China National Knowledge Infrastructure, Chinese Medical Current Contents, VIP, PubMed, Medline, Ovid, Elsevier, ISI Web of Knowledge, Cochrane Database of Systematic Reviews). With strictly screening according to the standard, the quality of studies was evaluated. Selective trials were analyzed by the Review Manager 5.1 software.</p><p><b>RESULTS</b>A total of eight nonrandomized clinical trials, involving a total of 1209 patients (615 patients in CME group and 594 patients in control group), were identified. Meta-analysis showed that the intraoperative blood loss in CME group was less than that in control group [WMD=-13.05, 95%CI-25.03 to -1.07, P=0.03]. No significant difference in the operation time was found [WMD=0.46, 95%CI-26.50 to 27.41, P=0.97], and significant differences in the number of lymph node retrieved from postoperative pathologic specimens, the average length of large bowel resected, the area of mesentery resected, and the high vascular ligation were revealed between two groups. Besides there were no significant differences in the time to first flatus and the hospital stay between two groups (P=0.87, P=0.05). The postoperative complication morbidity did not increase in CME group as compared to control group (P=0.74).</p><p><b>CONCLUSION</b>CME is safe and effective in accordance with the concept of embryonic anatomy, oncological surgery and delicate surgery, and is expected to become a standardization operation method for colon cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cirugía General
/
Estudios de Factibilidad
/
Ensayos Clínicos como Asunto
/
Neoplasias del Colon
/
Mesenterio
Tipo de estudio:
Ensayo Clínico Controlado
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2014
Tipo del documento:
Artículo
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