Sperm DNA integrity of infertile males with hepatitis B virus infection / 中华男科学杂志
National Journal of Andrology
;
(12): 72-76, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-256923
ABSTRACT
<p><b>OBJECTIVE</b>To investigate sperm DNA integrity in male infertility patients with hepatitis B virus (HBV) infection.</p><p><b>METHODS</b>This study included 90 infertile men with HBV infection (group A), 82 infertile men without HBV infection (group B) and 70 normal fertile men (group C). We detected sperm DNA integrity among the subjects, including DNA fragmentation index (DFI) and high DNA stainability (HDS), by sperm chromatin structure assay (SCSA), and compared them among the three groups.</p><p><b>RESULTS</b>DFI was higher in group A ([28.17 +/- 13.06]%) than in B ([26.64 +/- 9.79]%) and C ([15.67 +/- 4.73]%), significantly higher in A and B than in C (P < 0.05) but with no significant difference between A and B (P > 0.05). HDS was higher in group A ([10.83 +/- 5.601]%) than in B ([9.04 +/- 3.48]%) and C ([8.04-2.25]%), with significant difference between A and C (P < 0.05).</p><p><b>CONCLUSION</b>Sperm DNA integrity of infertile males is significantly different from that of normal fertile men, and infertility with HBV infection further impairs sperm DNA, which is manifested by abnormal sperm nuclear maturity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Recuento de Espermatozoides
/
Espermatozoides
/
Virología
/
Daño del ADN
/
ADN
/
Cromatina
/
Estudios de Casos y Controles
/
Virus de la Hepatitis B
/
Genética
Tipo de estudio:
Estudio observacional
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2013
Tipo del documento:
Artículo
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