Caspase-3 and survivin expression in pediatric neuroblastoma and their roles in apoptosis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1821-1824, 2004.
Artículo
en Inglés
| WPRIM
| ID: wpr-257353
ABSTRACT
<p><b>BACKGROUND</b>Neuroblastoma, one of the common tumors in children, possesses the feature of natural regression that might be related to apoptosis caspase-3 and survivin are believed to respectively induce and inhibit apoptosis. We investigated the expression of caspase-3 and survivin in pediatric neuroblastoma and the role that these genes played in apoptosis.</p><p><b>METHODS</b>The expression of caspase-3 and survivin in pediatric neuroblastoma tissue samples was detected using in situ hybridization, ter mintuesal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), and immunohistochemical staining. The role that these genes played in apoptosis was then evaluated.</p><p><b>RESULTS</b>A converse correlation was observed between the expression of survivin and caspase-3. When survivin was expressed at high levels in neuroblastoma samples, caspase-3 expression was downregulated, and the apoptotic index decreased simultaneously.</p><p><b>CONCLUSION</b>There is a converse correlation between the expression of caspase-3 and the expression of survivin in neuroblastoma cells, indicating that caspase-3 might induce apoptosis, and survivin may inhibit this process.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Inmunohistoquímica
/
Química
/
Apoptosis
/
Caspasas
/
Proteínas Inhibidoras de la Apoptosis
/
Caspasa 3
/
Proteínas Asociadas a Microtúbulos
/
Proteínas de Neoplasias
Límite:
Femenino
/
Humanos
/
Lactante
/
Masculino
/
Recién Nacido
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2004
Tipo del documento:
Artículo
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