Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Korean Journal of Pathology
;
: 142-150, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-25785
ABSTRACT
BACKGROUND:
It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.METHODS:
We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.RESULTS:
The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p0.05).CONCLUSIONS:
HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Acetilación
/
Pronóstico
/
Inmunohistoquímica
/
Linfocitos B
/
Histonas
/
Western Blotting
/
Linfoma de Células B
/
Linfoma de Células T Periférico
/
Seudolinfoma
/
Histona Acetiltransferasas
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Korean Journal of Pathology
Año:
2012
Tipo del documento:
Artículo
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