Regulation of pancreatic beta-cell function by adipocytes / 生理学报
Acta Physiologica Sinica
;
(6): 247-252, 2007.
Artículo
en Inglés
| WPRIM
| ID: wpr-258661
ABSTRACT
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fisiología
/
Adipocitos
/
Leptina
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
/
Adiponectina
/
Metabolismo de los Lípidos
/
Glucosa
/
Insulina
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS