Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 679-682, 2015.
Article
en En
| WPRIM
| ID: wpr-258891
Biblioteca responsable:
WPRO
ABSTRACT
Our study explored the dynamic changes in and the relationship between the DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the DNA repair marker 8-hydroxyguanine DNA glycosidase 1 (hOGG1) according to the length of occupational employment in nickel smelting workers. One hundred forty nickel-exposed smelting workers and 140 age-matched unexposed office workers were selected from the Jinchang cohort. The 8-OHdG levels in smelting workers was significantly higher than in office workers (Z=-8.688, P<0.05) and the 8-OHdG levels among nickel smelting workers in the 10-14 y employment length category was significantly higher than among all peers. The hOGG1 levels among smelting workers were significantly lower than those of non-exposed workers (Z=-8.948, P<0.05). There were significant differences between employment length and hOGG1 levels, with subjects employed in nickel smelting for 10-14 y showing the highest levels of hOGG1. Correlation analysis showed positive correlations between 8-OHdG and hOGG1 levels (r=0.413; P<0.01). DNA damage was increased with employment length among nickel smelting workers and was related to the inhibition of hOGG1 repair capacity.
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WPRIM
Asunto principal:
Factores de Tiempo
/
Orina
/
Sangre
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Daño del ADN
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Biomarcadores
/
Estudios de Casos y Controles
/
Desoxiadenosinas
/
Estudios de Cohortes
/
Exposición Profesional
/
ADN Glicosilasas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Año:
2015
Tipo del documento:
Article