Effect of delayed-release 5-fluorouracil implants on colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 57-59, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-259340
ABSTRACT
<p><b>OBJECTIVE</b>To study the antitumor effect of peri-tumor implantation of delayed-release 5-fluorouracil implants on xenograft colorectal tumor in mice.</p><p><b>METHODS</b>Fifty tumor-bearing nude mice were randomly divided into 5 groups. Group A and B were treated with peri-tumor implantation of 5-fluorouracil implants and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group C and D were treated with peri-tumor injection of 5-fluorouracil solution and the dose of 5-fluorouracil was 200 and 100 mg/kg, respectively. Group E did not receive any treatment. A growth curve was plotted for changes in tumor volume, the weight of the tumor was measured and tumor inhibition rate was calculated.</p><p><b>RESULTS</b>The growth curve was mild in group A and B and steep in group C, D and E. There were statistical differences in tumor volume between groups A and B and other groups and there were no statistical differences in tumor volume among group C, D and E. After 12 days, tumor inhibition rate was 72% in group A, 51% in group B, 8% in group C, and 5% in group C. There were statistical differences in inhibition rate between group A, B and C, D (P<0.05). The weight changes before and after the treatment among the 5 groups were not statistically different. During the study, 1 mouse in group A died, 4 in group C and 1 in group D.</p><p><b>CONCLUSION</b>Delayed-release 5-fluorouracil implants can effectively inhibit tumor growth.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Colorrectales
/
Ensayos Antitumor por Modelo de Xenoinjerto
/
Preparaciones de Acción Retardada
/
Quimioterapia
/
Fluorouracilo
/
Ratones Desnudos
/
Antimetabolitos Antineoplásicos
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2010
Tipo del documento:
Artículo
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