Sphingosine kinase 1 and tumor / 药学学报
Acta Pharmaceutica Sinica
;
(12): 971-978, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-259521
ABSTRACT
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) promotes cell survival and proliferation. The balance between ceramide/sphingosine and S1P forms a so-called "sphingolipid-rheostat", which decides the cell fate. Sphingosine kinases, which catalyze the phosphorylation of sphingosine to S1P, are critical regulators of this balance. Here, we review the role of sphingosine kinase 1 (SphK1) in regulating fundamental biological processes and tumorigenesis and the potential of SphK1 as a new target for cancer therapeutics.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Fosforilación
/
Esfingosina
/
Tiazoles
/
Lisofosfolípidos
/
Movimiento Celular
/
Ceramidas
/
Apoptosis
/
Fosfotransferasas (Aceptor de Grupo Alcohol)
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
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