A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity / 药学学报
Acta Pharmaceutica Sinica
;
(12): 891-895, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-259534
ABSTRACT
A novel sesquiterpenoid (1) and three known compounds identified as isoaltenuene (2), altenuene (3), and alternariol 4, 10-O-dimethyl ether (4), were isolated in our investigation of the cytotoxic constituents from solid cultures of the endophytic fungus Colletotrichum sp. The structures of these compounds were elucidated through spectroscopic data analysis. All compounds exhibited cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1. Compound 4 could induce the PANC-1 cells inflation or death, but couldn't induce apoptosis at the IC50 of 60.2 microg x mL(-1).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Sesquiterpenos
/
Estructura Molecular
/
Química
/
Apoptosis
/
Colletotrichum
/
Concentración 50 Inhibidora
/
Línea Celular Tumoral
/
Proliferación Celular
/
Lactonas
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2013
Tipo del documento:
Artículo
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