Recent advances of studies on abnormal HOX gene in myelodysplastic syndromes and its molecular mechanisms / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 261-265, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-259603
ABSTRACT
HOX gene encodes a group of homeodomain transcription factors which are highly conserved. The caudal-type homeobox (CDX) , ten-eleven translocation (TET) genes and polycomb group (PcG) , trithorax group (TrxG) proteins act as upstream regulators of HOX genes that manipulate the targeted gene expression through genetic and epigenetic mechanisms. The abnormal expression of HOX genes and their fusions contribute to myelodysplastic syndromes (MDS) pathogenesis. Aberrant DNA methylation and NUP98-HOX translocation serve as molecular mediators of dysfunction in MDS which can be used for the evaluation of biology and therapy. This article provides an overview of recent advances of studies on HOX gene and its abnormal molecular mechanisms, as well as potential correlation with MDS.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Translocación Genética
/
Síndromes Mielodisplásicos
/
Genes Homeobox
/
Proteínas de Drosophila
/
Epigénesis Genética
/
Proteínas de Unión al ADN
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS