Research advances on caspase-independent cell death of K562 cells / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1780-1784, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-259652
ABSTRACT
Caspase independent cell death (CICD) is defined as death that ensues when a signal that normally induces apoptosis fails to activate caspases,it can be activated by PARP-1, Calpains, Bax and AIF, possessing distinctive biologic characteristic differed from apoptosis and necrosis. Recent researchs have found that the molecular mechanisms governing CICD of K562 is opposite from that of the traditional medicine killing leukemia cells, which may have the potential pharmaceutical point for new drugs. This article reviews the newly acquaintance of molecular mechanisms for CICD and recent studies concerning the induction death of K562 cells via CICD, so as to provide some reference for the research of new drug point.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Calpaína
/
Poli(ADP-Ribosa) Polimerasas
/
Apoptosis
/
Células K562
/
Caspasas
/
Proteína X Asociada a bcl-2
/
Necrosis
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2014
Tipo del documento:
Artículo
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