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Monitoring depth of anesthesia and effect analysis in primary visual cortex of rats based on complexity of local field potential / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 245-250, 2014.
Artículo en Chino | WPRIM | ID: wpr-259662
ABSTRACT
In the present study carried out in our laboratory, we recorded local field potential (LFP) signals in primary visual cortex (V1 area) of rats during the anesthesia process in the electrophysiological experiments of invasive microelectrode array implant, and obtained time evolutions of complexity measure Lempel-ziv complexity (LZC) by nonlinear dynamic analysis method. Combined with judgment criterion of tail flick latency to thermal stimulus and heart rate, the visual stimulation experiments are carried out to verify the reliability of anesthetized states by complexity analysis. The experimental results demonstrated that the time varying complexity measures LZC of LFP signals of different channels were similar to each other in the anesthesia process. In the same anesthesia state, the difference of complexity measure LZC between neuronal responses before and after visual stimulation was not significant. However, the complexity LZC in different anesthesia depths had statistical significances. Furthermore, complexity threshold value represented the depth of anesthesia was determined using optimization method. The reliability and accuracy of monitoring the depth of anesthesia using complexity measure LZC of LFP were all high. It provided an effective method of realtime monitoring depth of anesthesia for craniotomy patients in clinical operation.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estimulación Luminosa / Corteza Visual / Reproducibilidad de los Resultados / Dinámicas no Lineales / Potenciales Evocados Visuales / Anestesia / Métodos / Microelectrodos / Monitoreo Fisiológico Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: Journal of Biomedical Engineering Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estimulación Luminosa / Corteza Visual / Reproducibilidad de los Resultados / Dinámicas no Lineales / Potenciales Evocados Visuales / Anestesia / Métodos / Microelectrodos / Monitoreo Fisiológico Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Chino Revista: Journal of Biomedical Engineering Año: 2014 Tipo del documento: Artículo