Expression of erythroblastic leukemia viral oncogene homolog 3 (ErbB-3) binding protein-1, matrix metalloproteinases, eplthelial cadherin in adenoid cystic carcinoma and correlation analysis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 711-714, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-260203
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of ErbB-3 binding protein-1 (EBP-1), matrix metalloproteinase 9 (MMP-9) and E-cadherin (E-cad) in adenoid cystic carcinoma and their correlation.</p><p><b>METHODS</b>Immunohistochemistry(PV6000 method) was used to detect EBP-1, MMP-9 and E-cad expression in 66 cases of adenoid cystic carcinoma tissues and matched para-cancerous normal tissues. In this study all cases were successfully followed up.</p><p><b>RESULTS</b>The positive expression rate of EBP-1 in adenoid cystic carcinoma tissues was 85%. EBP-1 expression was significantly correlated to pathological pattern and clinical stage (P < 0.05), but not to gender and age. In addition, there was a negative correlation between EBP-1 and E-cad expression, and positive correlation between EBP-1 and MMP-9.</p><p><b>CONCLUSIONS</b>EBP-1 and its correlation with MMP-9 and E-cad may be used as useful indicators for clinical assessment of tumor biological behavior and prognosis in patients with adenoid cystic carcinoma.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias de las Glándulas Salivales
/
Biomarcadores de Tumor
/
Cadherinas
/
Estudios de Seguimiento
/
Proteínas de Unión al ARN
/
Carcinoma Adenoide Quístico
/
Metaloproteinasa 9 de la Matriz
/
Proteínas Adaptadoras Transductoras de Señales
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2012
Tipo del documento:
Artículo
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