Analysis of the relationship between expression of caveolin-1 and prognosis in bladder transitional cell carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 429-431, 2010.
Article
en Zh
| WPRIM
| ID: wpr-260385
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the relationship between expressions of caveolin-1 and prognosis in bladder transitional cell carcinoma (BTCC).</p><p><b>METHODS</b>The expression of caveolin-1 was detected in 85 cases of BTCC. 64 cases of primary BTCC were followed-up after operation. The tumor-free survival time in recurrent BTCC patients was observed.</p><p><b>RESULTS</b>The positive expression rates of caveolin-1 in primary and recurrent BTCC were 32.8% and 61.9%, respectively, with a significant difference (P < 0.05). There was a significant difference (P < 0.05) between the tumor-free survival times in the groups with positive and negative expressions of caveolin-1. The half-, 1-, 2- and 3-year tumor-free survival rates in the group with positive expression of caveolin-1 were 90.4%, 80.9%, 66.3% and 56.1%, respectively. The half-, 1-, 2-, and 3-year tumor-free survival rates in the group with negative expression of caveolin-1 were 97.7%, 95.4%, 81.4% and 79.0%, respectively. The tumor-free survival rate in the group with positive expression of caveolin-1 was significantly lower than that in the group with negative expression of caveolin-1 (P < 0.05).</p><p><b>CONCLUSION</b>Positive expression of caveolin-1 in BTCC can be regarded as a high risk factor of recurrence of BTCC. Positive expression of caveolin-1 in BTCC is correlated with the prognosis of BTCC, and BTCC patients with positive expression of caveolin-1 should be followed-up after operation.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Cirugía General
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Neoplasias de la Vejiga Urinaria
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Carcinoma de Células Transicionales
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Cistectomía
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Tasa de Supervivencia
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Factores de Riesgo
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Estudios de Seguimiento
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Supervivencia sin Enfermedad
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Caveolina 1
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Año:
2010
Tipo del documento:
Article