The Effects on the MSG with Phenylalanine Treatment in the Area Postrema of the Rat Medulla / 체질인류학회지
Korean Journal of Physical Anthropology
; : 213-220, 2000.
Article
en Ko
| WPRIM
| ID: wpr-26042
Biblioteca responsable:
WPRO
ABSTRACT
Glutamate is an amino acid neurotransmitter capable of producing widespread receptor-mediated neuronal excitation. In this experiment, we examined the effect of saline, monosodium glutamate (MSG), phenylalanine and MSG-phenylalanine treatment on TH immunoreactivity in area postrema (AP) of medulla oblangata. An immunocytochemical method was used to visualize catecholaminergic neurons in the AP. Damage of TH neurons in the AP of adult Sprague-Dawley rats was induced by injection of MSG (4 mg/g bw) and was decreased by administration of MSG following phenylalanine treatment (15 mg/g bw). We conclude that phenylalanine protect from the neuroexcitotoxic effect of systemic glutamate.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Fenilalanina
/
Glutamato de Sodio
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Ratas Sprague-Dawley
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Neurotransmisores
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Ácido Glutámico
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Área Postrema
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Neuronas
Límite:
Animals
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Physical Anthropology
Año:
2000
Tipo del documento:
Article