A virological response study of serum leptin level and insulin resistance on the antivirus effect in patients with chronic hepatitis C / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 887-889, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-260561
ABSTRACT
<p><b>OBJECTIVE</b>To study the serum leptin level and insulin resistance on sustained virological response (SVR) in patients with chronic hepatitis C and to evaluate whether serum leptin level and insulin resistance are independent risk factors.</p><p><b>METHODS</b>Forty chronic hepatitis C patients were treated with interferon (alpha-2a) 5 MU and ribavirin 1.0 g for 24 weeks. The fasting serum leptin, insulin, glucose, HCV RNA load, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured and the insulin resistance index (HOMA-IR homeostasis model of assessment) and body mass index (BMI) were calculated. Statistical methods used were univariate analyses and multivariable regression analyses.</p><p><b>RESULTS</b>Of the 40 patients, 23 patients (57.5%) had a sustained virological response and 17 patients (42.5%) had a non-sustained virological response. Patients with a sustained virological response had lower serum leptin, HOMA-IR and BMI. Their SVR was associated with age, HCV RNA loads, serum leptin level, and insulin resistance, when analyzed with univariate analyses. SVR was not associated with sex, ALT, or AST. With multivariable regression analyses, serum leptin level and insulin resistance were found to be independent prediction factors for SVR in chronic hepatitis C patients with antivirus treatment.</p><p><b>CONCLUSION</b>Serum leptin level and insulin resistance were associated with SVR in chronic hepatitis C patients; they were independent prediction factors for SVR.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
Sangre
/
Resistencia a la Insulina
/
Hepacivirus
/
Hepatitis C Crónica
/
Leptina
/
Alergia e Inmunología
/
Insulina
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2006
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS