Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.</p><p><b>METHOD</b>36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.</p><p><b>RESULT</b>Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.</p><p><b>CONCLUSION</b>Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.</p>