Degradable performance and bio-mineralization function of PLA-PEG-PLA/PLA tissue engineering scaffold in vitro and in vivo / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1070-1075, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-260936
ABSTRACT
The degradable performance and bio-mineralization function of PLA-PEG-PLA/PLA tissue engineering scaffolds in vitro and in vivo were systematically studied. The X-ray diffraction and Fourier transform infrared spectra showed that there was the deposition of bone-like carbonate hydroxyapatite on the surface of scaffolds. We found that the weight of scaffolds did not always decrease with the prolongation of time in vitro. At the same time, we found that after the PLA-PEG-PLA/PLA tissue engineering scaffolds were embedded in skulls of rhesus monkeys, the new bone area reached 75% at the 12th week. Histological observation showed that the new bones were rebuilt and knitted bones were formed at the 12th week. These findings meant that the PLA-PEG-PLA/PLA tissue engineering scaffolds were potential in clinical use.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Polietilenglicoles
/
Polímeros
/
Cráneo
/
Materiales Biocompatibles
/
Regeneración Ósea
/
Química
/
Sustitutos de Huesos
/
Implantes Experimentales
/
Ingeniería de Tejidos
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2010
Tipo del documento:
Artículo
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