Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>The clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.</p><p><b>RESULT</b>aGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.</p><p><b>CONCLUSION</b>aGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.</p>