Study on plasma coagulation factor VII (FVII) levels and polymorphisms of FVII gene in patients with coronary heart disease / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 457-459, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-261384
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the plasma levels of coagulation factor VII (FVII) and polymorphisms of FVII gene in patients with coronary heart disease (CHD), and evaluate the effect of plasma FVII levels and FVII gene polymorphisms on CHD.</p><p><b>METHODS</b>Plasma FVIIa, FVII Ag and FVIIc were measured and polymorphisms of FVII gene were analyzed in 149 control cases and 60 CHD cases, including 33 acute myocardial infarction (AMI) cases by a combination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and agarose gel electrophoresis.</p><p><b>RESULTS</b>FVIIa, FVIIc in AMI group were significantly higher than that in control group, but FVII Ag wasn't. There were no significant difference in plasma FVIIa, FVII Ag and FVIIc between CHD and control group. The IVS7 genotypic frequency in AMI group was significantly different from that in control group. There was no significant difference in genotypic frequencies and allelic frequencies in other polymphism sites. FVII Ag was significantly higher in -402A homozygote than that in -402G homozygote.</p><p><b>CONCLUSIONS</b>Increased FVII levels, especially FVIIa and FVIIc in plasma, may contribute to coronary artery thrombosis. There was significant difference in IVS7 genotype frequency between control and AMI groups, but the rest weren't significantly different. FVII Ag was significantly higher in -402A homozygote than that in -402G homozygote. Polymorphism of -402 G/A may play an indirect role in AMI by regulating plasma FVII levels.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Sangre
/
Polimorfismo de Longitud del Fragmento de Restricción
/
Factor VII
/
Reacción en Cadena de la Polimerasa
/
Enfermedad Coronaria
/
Genética
/
Genotipo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hematology
Año:
2002
Tipo del documento:
Artículo
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