Polymorphism Study of Susceptibility Genes Related to Sporadic Alzheimer's Disease
Journal of the Korean Geriatrics Society
;
: 115-124, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-26143
ABSTRACT
Background:
We investigated whether any single nucleotide polymorphism of the 7 candidate susceptibility genes is associated with sporadic Alzheimer's disease (AD).Methods:
Genomic DNA from brain tissues of registered cases of autopsy-confirmed, sporadic AD (n=45) and from non-demented cerebral infarct with atherosclerosis (A/S, n=36) as a control group were isolated and single strand conformational polymorphism was done.Results:
287 base pair insertion/deletion (I/D) of angiotensin converting enzyme (ACE) was most frequent genotype in AD and infarct- A/S. Among (GT)18, (GT)19 and (GT)20 polymorphism, (GT)18 polymorphism in the promoter region of neprilysin (NEP) was most com- monly found in AD and infarct-A/S. CT genotype of NEP*159C>T in 3'-untranslated region was most frequent genotype in AD and infarct-A/S. ACE genotype and allele both were associated with the frequency of NEP (GT)n genotype (p<0.05) in AD. Polymorphisms of cathepsin D, nitric oxide synthase 3, low density lipoprotein receptor related-protein, G protein beta3-subunit and LBP-1c/CP2/LSF transcriptional factor were not related to AD.Conclusion:
Coexistence of ACE I/D and NEP (GT)n polymorphism appeared to be a genetic risk factor for sporadic AD in comparison with cerebral infarct-atherosclerosis.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Encéfalo
/
ADN
/
Receptores de LDL
/
Neprilisina
/
Factores de Riesgo
/
Catepsina D
/
Regiones Promotoras Genéticas
/
Peptidil-Dipeptidasa A
/
Óxido Nítrico Sintasa
/
Proteínas de Unión al GTP
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Idioma:
Coreano
Revista:
Journal of the Korean Geriatrics Society
Año:
2006
Tipo del documento:
Artículo
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