Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the association between CYP11B2 gene polymorphism and essential hypertension, blood pressure level in Chinese Han population by meta-analysis.</p><p><b>METHODS</b>After searching database, the research quality was quantified according to NOS. Genetic model, heterogeneity, publication bias, overall OR/standardized mean difference (SMD) and 95%CI were explored by Stata, 19 studies including 9249 subjects were included in this meta-analysis.</p><p><b>RESULTS</b>Compared to control group, OR(95%CI) of CC vs. TT, CT vs. TT, CC vs. CT in essential hypertensive patients were 1.022(95%CI 0.879-1.190), 1.108 (95%CI 0.951-1.291), 1.050(95%CI0.995-1.109), respectively; SMD (95%CI) was 0.315 (0.066-0.565, P < 0.05) for systolic pressure derived CC vs. TT, and 0.088 (0.014-0.162, P < 0.05) for CT vs.</p><p><b>TT CONCLUSION</b>Individuals with -344C CYP11B2 allele are at higher risk of increased systolic blood pressure, but there is no evidence showing association between CYP11B2 polymorphism and susceptibility of essential hypertension in Chinese Han population.</p>