Study on Helicobacter infection in liver tissue from hepatocellular carcinoma / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between Helicobacter species and hepatocellular carcinoma(HCC).</p><p><b>METHODS</b>Liver samples resected during operation from 34 patients with HCC diagnosed by histopathology and 20 without primary liver carcinoma as controls were studied. The two groups of sample were cranked out pathologic slice for in situ hybridization of Helicobacter, Helicobacter pylori and Helicobacter hepaticus. Qualitative and quantitative studies were used to assess the correlation of liver tissue Helicobacter infection with HCC.</p><p><b>RESULTS</b>64.71% (22/34). of the samples of HCC showed positive for Helicobacter specific 16S rRNA-mRNA gene by in situ hybridization, while none was positive in controls (P < 0.01).</p><p><b>CONCLUSION</b>Helicobacter pylori were found in the liver of patients with HCC.</p>