PML-RARα and p21 are key factors for maintaining acute promyelocytic leukemia stem cells survival / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1299-1302, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-261880
ABSTRACT
Tumor stem/progenitor cells are the cells with the characteristics of self-renewal, differentiating to all the other cell populations within tumor, which are also regarded as the source of tumor relapse, drug-resistance and metastasis. As a subtype of acute myeloid leukemia, acute promyelocytic leukemia (APL) represents the target of therapy due to the good response of the oncogenic protein PML-RARα to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). This review summarizes the latest research results of APL as follows (1) there probably are two APL stem/progenitor cell populations within APL, and self-renewal and survival of APL stem/progenitor cells highly depend on PML-RARα expression, cell cycle inhibitor p21, self-renewal associated molecules and chemokines; and (2) ATRA and ATO eradicate APL stem/progenitor cells mainly by PML-RARα degradation, FOXO3A activation and the inhibition of self-renewal-associated signaling pathway of sonic hedgehog. These findings are helpful to improve other tumor therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Células Madre Neoplásicas
/
Células Tumorales Cultivadas
/
Leucemia Promielocítica Aguda
/
Transducción de Señal
/
Proteínas de Fusión Oncogénica
/
Supervivencia Celular
/
Biología Celular
/
Inhibidor p21 de las Quinasas Dependientes de la Ciclina
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2011
Tipo del documento:
Artículo
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