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Dynamics of serum HBV DNA levels during the terminal phases of acute-on-chronic hepatitis B liver failure with different HBeAg status / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 522-525, 2012.
Artículo en Chino | WPRIM | ID: wpr-261961
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the dynamics and clinical significance of serum hepatitis B virus (HBV) DNA levels during the terminal phase of acute-on-chronic liver failure (ACLF) with different hepatitis B e antigen (HBeAg) status.</p><p><b>METHODS</b>One-hundred-and-seven patients with terminal ACLF were tested for HBeAg status by electrochemiluminescence immunoassay and serum HBV DNA levels by real-time PCR at three chronological time ranges, representing increasing severity of disease phases prior to death (day 0) 29-56 d, 15-28 d, and 0-14 d.</p><p><b>RESULTS</b>In the 37 HBeAg(+) patients, HBV DNA levels at above-mentioned phases were 6.10+/-1.63, 5.61+/-1.50, and 5.29+/-1.96 log10 copies/mL. In the 70 anti-HBe(+) patients, HBV DNA levels were 4.63+/-1.82, 5.81+/-1.78, and 4.93+/-1.73 log10 copies/mL. Phase to phase comparisons revealed that the HBV DNA level in the HBeAg(+) group was significantly higher than that in the anti-HBe(+) group at 29-56 d (P less than 0.05), and that 15-28 d and 0-14 d were not significantly different (P more than 0.05). Intragroup comparisons of phases revealed no significant differences in the HBeAg(+) group (P more than 0.05), but a significant difference between 15-28 d and 0-14 d (P less than 0.05) for the anti-HBe(+) group.</p><p><b>CONCLUSION</b>Serum levels of HBV DNA in patients with HBeAg positivity are higher than those in patients with anti-HBe positivity as the disease phase of ACLF nears fatality. Following the deterioration to liver failure, the HBV DNA load in HBeAg(+) patients remains stable while that in anti-HBe(+) patients decreases.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Virología / Sangre / ADN Viral / Virus de la Hepatitis B / Fallo Hepático Agudo / Carga Viral / Hepatitis B Crónica / Enfermedad Hepática en Estado Terminal / Genética Límite: Adolescente / Adulto / Anciano / Aged80 / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Virología / Sangre / ADN Viral / Virus de la Hepatitis B / Fallo Hepático Agudo / Carga Viral / Hepatitis B Crónica / Enfermedad Hepática en Estado Terminal / Genética Límite: Adolescente / Adulto / Anciano / Aged80 / Niño / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Hepatology Año: 2012 Tipo del documento: Artículo