Assessment of the factors associated with insulin resistance in patients with chronic hepatitis B infection / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 517-521, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-261962
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the factors associated with insulin resistance (IR) in patients with chronic hepatitis B virus (HBV) infection.</p><p><b>METHODS</b>Sixty-eight patients with mild chronic hepatitis B (MCHB) caused by HBV were recruited for study. Sixty-seven healthy individuals with no hepatitis virus infections and normal liver function were enrolled as controls. Demographic, anthropometric, clinical, and blood biochemical parameters were compared between the two groups. IR was determined by the homeostasis model assessment (HOMA-IR). The MCHB group was further divided into patients with IR (HOMA-IR > 2.7) and patients without IR (HOMA-IR less than 2.7). Demographic, anthropometric, clinical, and blood biochemical parameters were compared between the two sub-groups. Finally, the potential factors associated with IR were evaluated.</p><p><b>RESULTS</b>Compared to the healthy controls, the MCHB patients had significantly higher serum insulin (Z = -5.451, P less than 0.01), alanine aminotransferase (ALT) (Z = -8.211, P less than 0.01) and HOMA-IR (Z = -5.631, P less than 0.01). IR was detected in 44.12% (30/68) of the MCHB patients. The levels of ALT and body mass index (BMI) were significantly different between the MCHB patients with IR and without IR (t = -2.358, and t = -3.566, P less than 0.05). There was a significant correlation between BMI, ALT, and HOMA-IR in the MCHB patients (r = 0.374, r = 0.282, P less than 0.05), but not with the HBV DNA loads (r = 0.015, P = 0.904). Binary logistic regression analysis indicated that BMI [Exp(B) 1.859, P less than 0.01] and ALT [Exp(B) 1.022, P less than 0.05] were independent risk factors of IR in MCHB.</p><p><b>CONCLUSION</b>There is a high prevalence of insulin resistance in patients with mild hepatitis caused by chronic HBV infection. In these patients, IR is correlated with abnormal liver function and BMI, and not HBV load.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Virología
/
Sangre
/
Glucemia
/
Resistencia a la Insulina
/
Índice de Masa Corporal
/
Estudios de Casos y Controles
/
Virus de la Hepatitis B
/
Carga Viral
/
Hepatitis B Crónica
/
Alanina Transaminasa
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Hepatology
Año:
2012
Tipo del documento:
Artículo
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