Effects of warming-needle therapy on gene expression pathways in the patient with knee osteoarthritis of deficiency-cold syndrome / 中国针灸
Chinese Acupuncture & Moxibustion
;
(12): 677-680, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-262092
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of warming-needle therapy in treatment of knee osteoarthritis of deficiency-cold syndrome.</p><p><b>METHODS</b>Eight cases of knee osteoarthritis of deficiency-cold syndrome were selected and treated with warming-needle therapy at Guanyuan (CV 4), Qihai (CV 6) , Zosanli (ST 36), etc.. The gene expression profiles before and after treatment in 4 cases who showed better therapeutic effect were compared. Taking ratio < 0.5 or ratio > 2.0 as differentially expression gene and obtaining differentially expression pathway (P < 0.5, n>3) by http//www. DAVID 2006.</p><p><b>RESULTS</b>Two cases were clinically cured, 4 cases were markedly effective, 1 case was effective and 1 case was ineffective. With help of the microarray, 449 differentially expression genes, and 10 differentially expression pathways were obtained including 2 energy metabolism pathways (oxidative phosphorylation, ATP synthetase), 4 cell signal transduction pathways (insulin signal pathway, Toll-like receptor signal pathway, JAK-STAT signal pathway, and MAPK signal pathway) and cell apoptosis pathway.</p><p><b>CONCLUSION</b>Warming-needle therapy is an effective therapy for knee osteoarthritis with deficiency-cold syndrome , which is possibly involved in the control and regulation of many gene expression by various signal transduction pathways.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
Terapia por Acupuntura
/
Regulación de la Expresión Génica
/
Deficiencia Yang
/
Osteoartritis de la Rodilla
/
Sistema de Señalización de MAP Quinasas
/
Perfilación de la Expresión Génica
/
Factores de Transcripción STAT
/
Quinasas Janus
/
Factor 88 de Diferenciación Mieloide
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Acupuncture & Moxibustion
Año:
2007
Tipo del documento:
Artículo
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