Effect of ceftiofur hydrochloride on pharmacokinetics of matrine in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1859-1861, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-262240
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of ceftiofur hydrochloride on the pharmacokinetics of matrine in rats.</p><p><b>METHOD</b>The rats were divided into two groups one group was administrated with matrine only (control group) and the other was administrated with matrine in combination with ceftiofur hydrochloride. HPLC-UV method was used for determining the plasma concentration of matrine in both groups. The pharmacokinetic parameters were calculated from the plasma concentration-time data using the DAS 2. 1. 1 software program.</p><p><b>RESULT</b>The main pharmacokinetic parameters for the control group were C(max) = 21.113 9 mg x L(-1), T(max) = 0.75 h, t1/2alpha = 1.34 h, t1/2beta = 3.509 h, AUC(0-t) = 90.984 mg x h(-1) x L(-1) and AUC(0-inifinity) = 100.346 mg x h(-1) x L(-1), and the data for the combination group were C(max) = 11.707 mg x L(-1), T(max) = 0.917 h, t1/2alpha = 1.598 h, t1/2beta = 3.247 h, AUC(0-t) = 53.28 mg x h(-1) x L(-1) and AUC(0-inifinity) = 60.035 mg x h(-1) x L(-1).</p><p><b>CONCLUSION</b>The plasma concentration of matrine and bioavailability in combination group were significantly lower than those of the control group. In combination group, matrine had a higher clearance and volume of distribution in the central compartments, as well as a lower volume of distribution in the peripheral compartments.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Quinolizinas
/
Sangre
/
Farmacocinética
/
Distribución Aleatoria
/
Cefalosporinas
/
Ratas Sprague-Dawley
/
Interacciones Farmacológicas
/
Alcaloides
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2010
Tipo del documento:
Artículo
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