Chemical constituents of Alisma orientalis and their immunosuppressive function / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 994-998, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-263084
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents with immunosuppressive function from Alisma orientalis.</p><p><b>METHOD</b>The chemical constituents were isolated and purified by kinds of column chromatography and its structures were elucidated by NMR spectra and physicochemical properties. Its immunocompentence of lymphocytes taken from spleen of mouse were examined by MTT assay.</p><p><b>RESULT</b>Twelve compounds were isolated and identified as clovandiol (1), orientalol E (2), alismoxide (3), alismol (4), 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en (5), alismorientols A (6), alisol F (7), alisol A (8), 13beta,17beta-epoxy alisol A (9), alisol B 23-acetate (10), 1H-indole-3-carboxylic acid (11) and cuccinic acid (12). Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function.</p><p><b>CONCLUSION</b>Compounds 1, 5, 11 and 12 were isolated firstly from this genus,and the NMR spectra data of 1 were corrected firstly, some protostan-type triterpenoids may be developed as new drug with immunosuppressive function.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Sesquiterpenos
/
Triterpenos
/
Medicamentos Herbarios Chinos
/
Espectroscopía de Resonancia Magnética
/
Linfocitos T
/
Células Cultivadas
/
Química
/
Colestenonas
/
Biología Celular
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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