Study on linkage between polymorphism of interleukin 6 gene -572C/G and susceptibility to myocardial infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 245-249, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-263804
ABSTRACT
<p><b>OBJECTIVE</b>To observe the polymorphism and gene frequency of interleukin 6 (IL6) gene -572C/G in Chinese Han nationality population, that associating with susceptibility to myocardial infarction(MI) and impacting on the extent of coronary artery lesions; to analyze the function of IL6 gene -572C/G polymorphism.</p><p><b>METHODS</b>With PCR-RFLP method, IL6 gene -572C/G polymorphism was genotyped to 232 MI patients and 260 healthy adults. The effect of IL6 gene -572C/G polymorphism was observed to the extent of coronary artery lesions and the ability of IL6 production from peripheral blood mononuclear cells (PBMC).</p><p><b>RESULTS</b>There was IL6 gene -572C/G polymorphism in Chinese Hans. -572CG+GG genotype and G allele were more frequent in patients than in controls (P< 0.01). The relative risk for G allele carrier to suffer from MI was 1.68 times of CC genotype individual (95%CI 1.17-2.41, P< 0.01). However, the distribution of IL6 gene -572C/G polymorphism was no significant difference among patients with single-vessel, two-vessel and three-vessel lesions (P> 0.05). After PBMC cultured for 24 hours, the IL6 concentration in supernatant was significantly higher in subjects with CG genotype than those with CC genotype (P< 0.05).</p><p><b>CONCLUSION</b>IL6 gene -572G allele may be a genetic susceptibility factor to MI attack of Chinese Hans population, and related to the high expression of IL6.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo de Longitud del Fragmento de Restricción
/
Reacción en Cadena de la Polimerasa
/
Interleucina-6
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Frecuencia de los Genes
/
Genética
/
Genotipo
/
Infarto del Miocardio
Tipo de estudio:
Estudio de etiología
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Medical Genetics
Año:
2006
Tipo del documento:
Artículo
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