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The research on the correlation between eotaxin-3 gene polymorphisms and allergic asthma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 169-172, 2006.
Artículo en Chino | WPRIM | ID: wpr-263827
ABSTRACT
<p><b>OBJECTIVE</b>To study in the linkage between eotaxin-3 gene polymorphisms and allergic asthma susceptivity, blood plasma IgE or peripheral blood eosinophil in adult population of Han nationality from Hubei province of China.</p><p><b>METHODS</b>Polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP), tetra-primer PCR technique and restriction analysis were applied to identify the single nucleotide polymorphism.</p><p><b>RESULTS</b>The allele frequency of eotaxin-3 +2497 G, total levels of plasma IgE and peripheral blood eosinophil counts revealed the significant difference between control and allergic asthma group, that the P value was 0.011, 0.021 or 0.029 respectively. The allele frequency of eotaxin-3 +77 T and total levels of plasma IgE showed to have no significant difference between control and allergic asthma group, that the P value was 0.824 and 0.473 respectively. However, the peripheral blood eosinophil counts was significantly different between control and allergic asthma group, and the P value was 0.044.</p><p><b>CONCLUSION</b>Single nucleotide polymorphism of eotaxin-3 +2497 is associated with the asthma susceptibility, peripheral eosinophil counts and total levels of plasma IgE in adult population from Hubei province, and polymorphism of +77 is associated with peripheral eosinophil counts.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Asma / Sangre / Inmunoglobulina E / Análisis Mutacional de ADN / Datos de Secuencia Molecular / Secuencia de Bases / China / Quimiocinas CC / Predisposición Genética a la Enfermedad Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Asma / Sangre / Inmunoglobulina E / Análisis Mutacional de ADN / Datos de Secuencia Molecular / Secuencia de Bases / China / Quimiocinas CC / Predisposición Genética a la Enfermedad Límite: Adulto / Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Chino Revista: Chinese Journal of Medical Genetics Año: 2006 Tipo del documento: Artículo