Effect of Chinese bushen huatan drugs on pituitary-sex gland-immune axis in smoking induced chronic bronchitis mice / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 379-381, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-264134
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Chinese Bushen Huatan Drugs (BSHT, Chinese drugs for Kidney tonifying and phlegm resolving) on pituitary-sex gland-immune axis in smoking induced mice model of chronic bronchitis.</p><p><b>METHODS</b>Model mice were induced by smoking and divided into the model control group, the large dosage of BSHT group, the small dosage of BSHT group and the positive control group (treated by Guilong Kechuanning, a proved effective Chinese patent drug). A blank group of normal mice was also set for control. Serum levels of testosterone (T), luteotropic hormone (LH), interleukin-2 (IL-2), interleukin-8 (IL-8), visceral indexes of testis, epididymis and thymus were measured and microstructure of testis tissue was also observed.</p><p><b>RESULTS</b>As compared with those in the blank group, serum T, LH and IL-2 levels, and testis, epididymis and thymus indexes were all lower, and IL-8 level was higher in the model control group, moreover, atrophic change of testis was present in the model mice. These abnormal changes were all improved in the BSHT groups.</p><p><b>CONCLUSION</b>Smoking induced mice model of chronic bronchitis, which may cause reproductive endocrine disturbance and immunosuppression. BSHT could modulate the pituitary-sex gland-immune axis through adjusting the disturbed sex hormone, improve the pathological change of testis and enhance the immunity of organism.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Hipófisis
/
Testículo
/
Testosterona
/
Sangre
/
Hormona Luteinizante
/
Medicamentos Herbarios Chinos
/
Fumar
/
Distribución Aleatoria
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2002
Tipo del documento:
Artículo
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