Effect of ligustrazine on bone marrow hematopoiesis in mice after bone marrow transplantation / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 365-368, 2002.
Artículo
en Chino
| WPRIM
| ID: wpr-264138
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of ligustrazine (LT) on hematopoiesis in mice after bone marrow isotransplantation (iso-BMT).</p><p><b>METHODS</b>The typical model of iso-BMT was established and the model mice were randomly divided into two groups, the LT group treated with LT injection 0.2 ml and the control group treated with normal saline 0.2 ml, twice a day by gastrogavage. The following parameters were observed in the day 1, 7 and 14 peripheral blood cells, bone marrow mono-nuclear cells (BMMNC), heparin sulfate (HS) expression in bone marrow section by immunohistochemical SABC-AP method, stromal cell derived factor-1 (SDF-1) expression and CXC chemotaxis factor receptor 4 (CXCR4) expression.</p><p><b>RESULTS</b>The levels of peripheral WBC, platelet, BMMNC, CXCR4, HS, SDF-1 at the day 7 and 14 in the LT group were all higher significantly than those in the control group (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>LT could improve the bone marrow hematopoiesis in the early hematopoietic re-establishing stage after BMT.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pirazinas
/
Sangre
/
Leucocitos Mononucleares
/
Distribución Aleatoria
/
Trasplante de Médula Ósea
/
Receptores CXCR4
/
Hematopoyesis
/
Ratones Endogámicos BALB C
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2002
Tipo del documento:
Artículo
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